Unbeaten Bills Host Struggling Chargers in Week 3 Test
The Buffalo Bills host the Los Angeles Chargers on Sunday, September 27, 2026, at 1 p.m. ET at Highmark Stadium in Orchard Park, New York. Buffalo enters at 2-0, while Los Angeles is winless through two games at 0-2. The Bills are listed as 7-point favorites.
Josh Allen has powered Buffalo's fast start, throwing for 582 yards and five touchdowns without a turnover as the Bills have scored 77 points over two games and converted 57.1 percent of their third downs. Tight end Dalton Kincaid has been his top target, leading the team with 225 receiving yards and 12 catches to go with a touchdown. The Chargers' defense has struggled in response, allowing 393 total yards and 26 points per game while managing just three sacks. bet mpl
Los Angeles has had the opposite experience on offense. Justin Herbert has thrown for 370 yards with two touchdowns and three interceptions, including a 192-yard, two-interception showing in a Week 2 loss to the Raiders that left his passer rating at 71.6. The Chargers carry a minus-4 turnover margin into Buffalo, a problem against a Bills defense that already has seven sacks, tied for fourth most in the league, despite allowing 31 points per game. Running back Omarion Hampton has been a bright spot, scoring a rushing touchdown in each game and totaling 94 yards on 23 carries in Week 2 against a Buffalo run defense that has surrendered 95 yards per game and 3.7 yards per carry.
The contrast in form sets up a clear storyline: Buffalo's efficient, mistake-free offense against a Los Angeles defense still searching for answers, and a Chargers offense trying to protect the ball against a Bills pass rush that has been opportunistic early in the season.
